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KMID : 0363220130510100809
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Korean Journal of Dermatology
2013 Volume.51 No. 10 p.809 ~ p.813
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Cutaneous Rosai-Dorfman Disease (RDD) Mimicking Primary Cutaneous Marginal Zone B-cell Lymphoma
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Noh Tai-Kyung
Won Kwang-Hee
Rhee Do-Young
Won Chong-Hyun
Chang Sung-Eun
Lee Mi-Woo
Choi Jee-Ho
Moon Kee-Chan
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Abstract
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Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is an idiopathic, benign, histiocytic proliferative disease involving lymph nodes and extranodal sites. A 52-year-old woman presented with a 2-year history of multiple non-tender, erythematous nodules on her face. The initial punch biopsy showed lymphoid follicle-like aggregation of CD20 positive lymphocytes in the papillary dermis consisting of primary cutaneous marginal zone B-cell lymphoma. She underwent a 3-month course of radiotherapy, but the lesions progressed. The re-biopsy specimen revealed marked histiocytes with positive CD68 and S-100 proteins. The patient was treated with prednisolone and isotretinoin to which she responded slightly. Repeated histopathologic examinations enable us to make a definite diagnosis. Differentiating these two disorders as early as possible is crucial for appropriate treatment.
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KEYWORD
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Rosai-Dorfman disease, Sinus histiocytosis with massive lymphadenopathy
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